State-of-the-Art Technologies for Studying Cellular and Molecular Mechanisms Underlying Alzheimer's Disease

Alzheimer's disease (AD) is the most common neurodegenerative and cause of dementia. It associated with progressive cognitive decline due to development cortical hippocampal atrophy.
 We reviewed key factors in AD pathogenesis, such as synaptic dysfunction, accumulation aggregation amyloid beta (A) peptide, tau phosphorylation causing neurofibrillary tangles, mitochondrial neuroinflammation. studied dysbiosis role demonstrated how much bidirectional communication between gut brain sheds new light on some pathogenic processes underlying AD. state-of-the-art biomedical technologies for studying AD: transgenic models, electrophysiological techniques, optogenetics, multi-omics approaches, neuroimaging, etc. New significantly expanded our current knowledge pathogenesis laid groundwork treatment approaches.